Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders. SSRIs are believed to increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor. They have varying degrees of selectivity for the other monoamine transporters, with pure SSRIs having only weak affinity for the norepinephrine and dopamine transporters. SSRIs are the most widely prescribed antidepressants in many countries. The main indication for SSRIs is major depressive disorder (also called "major depression", "clinical depression" and often simply "depression"). SSRIs are frequently prescribed for anxiety disorders, such as social anxiety disorder, panic disorders, obsessive–compulsive disorder (OCD), eating disorders, chronic pain and occasionally, for posttraumatic stress disorder (PTSD). They are also frequently used to treat depersonalization disorder, although generally with poor results. Antidepressants are recommended by the National Institute for Health and Care Excellence (NICE) as a first-line treatment of severe depression and for the treatment of mild-to-moderate depression that persists after conservative measures such as cognitive therapy. I would move to a new class of antidepressants that also have antipanic properties, ie, serzone which has a different mechanism of action or to an older type of antidepressant such as imipramine or chlorimipramine. Reason being, while both meds are SSRIs, the specific and intricate mechanism of action of each med varies quite a bit. Therefore, you could be experiencing a form of a discontinuation syndrome (fancy term for a w/d like situation). The good news is, introducing the Zoloft WILL help to minimize the severity of those symptoms. Again, your dizziness could be caused by several different things, no one can say for sure, but yes, you are correct that your theory is a possibility. The Zoloft dose seems to be pretty close to the Paxil dose, although due to all of these meds varying in mechanism of action, it is impossible to find a perfect dose to start at with the new med...each individual person. I think breaking up the Zoloft dose like he did will be helpful to you as well.
Facts about Sertraline Zoloft -Mechanism of Action Sertraline has dopamine reuptake inhibition DRI and sigma 1. receptor binding in addition to serotonin reuptake inhibition. The DRI effects may. improve energy, motivation and concentration. The sigma properties may improve. anxiety and psychotic symptoms in psychotic depression Stahl, 2013. Antidepressant. Pharmacology Pharmacodynamics Sertraline is a potent and selective inhibitor of neuronal serotonin 5-HT uptake in vitro, which results in the.