There has been an argument on whether or not Zoloft gives a high feeling to someone using it beyond the prescribed dose. While some might have claimed of having such experience after taking it regularly and at an increased amount, there have been no clinical studies yet that may prove this claim. Zoloft, which carries the generic name Sertraline, is an anti-depressant drug that belongs to the class of selective serotonin reuptake inhibitor (SSRI). It is commonly prescribed to treat anxiety disorders, obsessive-compulsive disease, and depression. The popularity of the drug could be attributed to the fact that it has less cardiovascular, anticholinergic, and sedative effects on the patient, among other things. Other common SSRI drugs are Prozac (fluoxetine), Paxil (paroxetine), and Celexa (citalopram). It is worth noting that this drug may give a feeling of being lifted because of depression slowly going away but that is not exactly getting high. However, an improvement on the patient’s condition can be observed as early as one to two weeks. Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo.
Sep 2, 2017. Zoloft sertraline is a selective serotonin reuptake inhibitor SSRI. Learn how it works to elevate mood and how it is used to treat conditions. Drug Information on Zoloft sertraline includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.