They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry. Nearly all quinolone antibiotics in use are fluoroquinolones, which contain a fluorine atom in their chemical structure and are effective against both Gram-negative and Gram-positive bacteria. One example is ciprofloxacin, one of the most widely used antibiotics worldwide. Fluoroquinolones are often used for genitourinary infections and are widely used in the treatment of hospital-acquired infections associated with urinary catheters. In community-acquired infections, they are recommended only when risk factors for multidrug resistance are present or after other antibiotic regimens have failed. However, for serious acute cases of pyelonephritis or bacterial prostatitis where the person may need to be hospitalised, fluoroquinolones are recommended as first-line therapy. Due to people with sickle-cell disease being at increased risk for developing osteomyelitis from the Salmonella, fluoroquinolones are the "drugs of choice" due to their ability to enter bone tissue without chelating it, as tetracyclines are known to do. Quinolone antibiotics (including ciprofloxacin) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide). Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant. This medication may make a certain muscle condition (myasthenia gravis) worse. Tell your doctor right away if you have new or worsening muscle weakness (such as drooping eyelids, unsteady walk) or trouble breathing.
Multiple causes often contribute to the same Achilles tendon injury. For example: a sudden increase in hill climbing, worn out shoes, and weak or tight calf muscles could all contribute to Achilles tendinosis and Achilles tendonitis. The quinolone group of antibiotics are used to treat a wide range of bacterial infections, but weaken some people’s tendons. The weakness is most often felt in the Achilles tendon because it is one of the largest and most heavily used tendons. The weakness may be felt as Achilles tendon soreness, or if it is severe enough, can lead to a rupture. Ciprofloxacin (Cipro®, Cipro XR®, Baycip®, Cetraxal®, Ciflox®, Cifran®, Ciplox®, Cyprobay®, Proquin XR ®, Quintor®), Floxo®, Gemifloxacin (Factive®), Levofloxacin (Levaquin®), Moxifloxacin (Avelox®), Norfloxacin (Noroxin®), and Ofloxacin (Floxin®). Back in August, we saw how a rehab program consisting of eccentric heel drops with a bent and straight knee reversed damage to the Achilles tendon by inducing collagen remodeling. One thing I didn't make clear enough is that Alfredson's eccentric heel drop protocol, developed in 1998, was designed for midpoint Achilles tendonitis. In most cases of Achilles injury, the tendon is damaged between 2 and 6 cm from the insertion point at the calcaneus (heel) bone. But in a minority of cases, the tendon is damaged at the insertion point—right at the heel bone. While it might seem like a trivial difference, these are actually parsed into two separate injuries. While both are the result of damage to the collagen fibers, the surrounding tissue at the insertion of the Achilles tendon is very different from the tissue near the midpoint of the Achilles. Insertional Achilles tendonitis is fairly easily differentiated from midpoint Achilles tendonitis based on where the pain is localized.
Antibiotic Drugs Ciprofloxacin. It is the most potent first generation bactericidal fluoroquinolone active against a wide range of bacteria. Fluoroquinolone antibiotic tendonitis is not ‘ordinary’ tendonitis caused from inflammation and overuse like the kind that people get from working on computers all day. Fluoroquinolone tendonitis is caused by a vicious cycle of the antibiotics reacting with your unique set of underlying health problems and genetic quirks.