You should not use this medication if you have a serious heart problem (heart block, sick sinus syndrome, slow heart rate), severe circulation problems, severe heart failure, or a history of slow heart beats that caused fainting. Metoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins). Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Metoprolol may also be used for other purposes not listed in this medication guide. You should not use this medication if you are allergic to metoprolol, or other beta-blockers (atenolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, propranolol, sotalol, and others), or if you have: Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. If you are being treated for high blood pressure, keep using this medication even if you feel well. You may need to use blood pressure medication for the rest of your life. Other drugs may interact with metoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Do not take this medicine in larger or smaller amounts or for longer than recommended. While using metoprolol, you may need frequent blood tests at your doctor's office. If you need surgery, tell the surgeon ahead of time that you are using metoprolol. Not all possible interactions are listed in this medication guide. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Metoprolol succinate (Toprol-XL) belongs to a group of drugs called beta-blockers. Doctors commonly prescribe this drug to treat high blood pressure, heart failure and heart-related chest pain called angina. Metoprolol succinate ER is a long-acting, once daily form of metoprolol. A wide variety of side effects are possible with metoprolol succinate, ranging from nausea and fatigue to potentially serious heart rhythm abnormalities and shortness of breath. The 50-mg dose of metoprolol succinate ER is a mid-range amount. Side effects might be more common with higher doses. The most common side effects of metoprolol succinate relate to its actions as a beta-blocker. It prevents the hormone adrenaline from binding to matching receptors in the brain, heart, blood vessels and kidneys.
Metoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins). Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Metoprolol is also used to lower your risk of death or needing to be hospitalized for heart failure. You should not use metoprolol if you have a serious heart problem (heart block, sick sinus syndrome, slow heart rate), severe circulation problems, severe heart failure, or a history of slow heart beats that caused fainting. You should not use this medicine if you are allergic to metoprolol, or other beta-blockers (atenolol, carvedilol, labetalol, nadolol, nebivolol, propranolol, sotalol, and others), or if you have: Do not give this medicine to a child without medical advice. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether metoprolol will harm an unborn baby. Metoprolol can help reduce your symptoms if you have too much thyroid hormone in your body (thyrotoxicosis). You'll usually take it together with medicines to treat an overactive thyroid. This medicine comes as tablets and is only available on prescription. It's also given by injection, but this is usually done in hospital. Your doctor may advise you to take your first dose before bedtime because it could make you feel dizzy. If you don't feel dizzy after the first dose, take metoprolol in the morning. If you have metoprolol more than once a day, try to space the doses evenly throughout the day.
Absorption: Well absorbed after oral administration. Distribution: Crosses the blood-brain barrier, crosses the placenta; small amounts enter breast milk. Metabolism and Excretion: Mostly metabolized by the liver (primarily by CYP2D6; the CYP2D6 enzyme system exhibits genetic polymorphism); ~7% of population may be poor metabolizers and may have significantly ↑ metoprolol concentrations and an ↑ risk of adverse effects. TIME/ACTION PROFILE (cardiovascular effects)When switching from immediate-release to extended-release product, the same total daily dose can be used PO: (Adults) Antihypertensive/antianginal– 25–100 mg/day as a single dose initially or 2 divided doses; may be ↑ q 7 days as needed up to 450 mg/day (immediate-release) or 400 mg/day (extended-release) (for angina, give in divided doses). MI– 25–50 mg (starting 15 min after last IV dose) q 6 hr for 48 hr, then 100 mg twice daily. Heart failure– 12.5–25 mg once daily (of extended-release), can be doubled every 2 wk up to 200 mg/day. Migraine prevention– 50–100 mg 2–4 times daily (unlabeled). IV: (Adults) MI– 5 mg q 2 min for 3 doses, followed by oral dosing. Tablets (tartrate): 25 mg, 50 mg, 100 mg Cost: Generic: All strengths $7.18/100Extended-release tablets (succinate; Toprol XL): 25 mg, 50 mg, 100 mg, 200 mg Cost: Generic: 25 mg $35.68/100, 50 mg $41.93/100, 100 mg $53.95/100, 200 mg $84.54/100Solution for injection: 1 mg/m LIn Combination with:hydrochlorothiazide (Dutoprol, Lopressor HCT). See combination drugs.metoprolol is a sample topic from the Davis's Drug Guide. • Hypertension • Angina pectoris • Tachyarrhythmias, in particular supraventricular tachycardia • Maintenance treatment after a myocardial infarction • Prophylaxis of migraine Metoprolol is indicated in adults. Metoprolol tartrate tablets should be administered orally. The dose must always be adjusted to the individual requirements of the patient. The following are guidelines: Hypertension The usual dose is 100mg to 200mg daily, given as a single dose in the morning, or in divided doses (morning and evening). Dose increments should be at weekly intervals thereafter according to individual patient responses. If necessary, it may be taken in combination with other antihypertensive drugs. Angina pectoris The usual dose is 100 to 200 mg daily, given in divided doses (morning and evening). Dose increments should be at weekly intervals thereafter according to individual patient responses. Maximum dose, usually 200mg daily (in divided doses). If necessary, it may be taken in combination with other antianginal drugs. Cardiac arrhythmias The usual dose is 100 to 150 mg per day, in divided doses (in the morning and in the evening). Myocardial infarctions The oral treatment can be initiated once the patient is haemodynamically stable.
Find patient medical information for Metoprolol Succinate Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user. NHS medicines information on metoprolol - what it's used for, side effects. For high blood pressure standard release - 50mg to 100mg twice a day; slow.