Most SJIA kids whose disease is not controlled by biologic drugs take glucorticoid steroids of some kind (prednisone is the most common). Steroids work well in controlling inflammation, but come at a tremendous cost: stunted growth, fragile bones, cataracts, and weakened muscle are some of the side-effects. But we put up with it because the alternative of uncontrolled SJIA is worse. Eric Hoffman, a researcher in another childhood disease (Duchenne Muscular Dystrophy), gave the keynote at our next-gen SJIA treatments conference in October. He is leading an effort at Reveragen to bring a steroid replacement called Vamorolone (generic name VBP15) to market. The goal of the drug is to replicate the good effects of steroids (primarily their anti-inflamatory effect) without the side effects. The way that the drug works is by modifying steroids so that the transrepression effects are removed. Currently I have been on prednisone for a year now. They brought me down to 5mg a day and now I am fully flairs and swollen in the face, eye lids, middle of my back, lower back, arthritis spots etc. I am only 34yrs old and worry that this might be something i need to take forever. ** right now I am currently on two 200mg celebrex a day, 3 ultram a day, 5mg prednisone, Arava, 150mg iron. Osteoporosis, increased risk of heart disease, increased risk of infections, weight gain are all assocaited with low dose prednisone use. I was told this could happen as a reaction to tapering off, but don’t know if that is what is going on or if I need more medication. There has been increased recognition on the long term side effects of prednisone based on clinical studies. I heard of the hardening of arteries, the knee replacements etc. I figure with my case of RA as bad as it is and having Fibro as well as a bad case of iron deficiency anemia, that this drug just might be with me forever. Is there a more safe dose to take for the body long term at my age that can help prevent the long term damage? Are there any drugs or herbal suppliments I can take to help fight against the effects of prednisone so taking 7mg a day might be ok for the rest of my life? Are there any sub drugs out there to take instead that might work as well? Medications such as methotrexate, Arava, the anti-TNF drugs (Enbrel, Humira, Remicade) are all used to try to reduce prednisone.
Any alternatives for Prednisone. Question. Currently I have been on prednisone for a year now. I was doing ok at 7mg but not as good as 10. Prednisone Alternative Systemic Enzymes A Natural Alternative to Prednisone? Prednisone works by blocking "key steps in the allergic and inflammatory response, including the production and secretion of the so-called inflammatory mediators such as