The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Sildenafil (brand name Viagra) is a phosphodiesterase 5 (PDE5) inhibitor. It is one of the Top 250 Drugs (similar to the Top 200 Drugs or Top 300 Drugs) in Clin Calc.com's Flash RX mobile app and The Top 250 Drugs online educational video course. Do you wish you could review the top 250 drugs from beginning to end? Sign up for our stellar online video series, The Top 250 Drugs. This course uses 60 succinct, high-yield videos and brief comprehension quizzes to help you develop a rock-solid understanding of the top 250 medications.
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