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Valacyclovir Oral Route Side Effects - Mayo Clinic

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, a series in which we track down the best hygiene-, sex-, and bodily function–related things we all need but might be too embarrassed to ask about. adults that get cold sores, the painful skin bumps that flare up when the immune system’s compromised (most often but not strictly around the mouth and nose) are likely a recurring problem. In this installment, we discuss the best cold-sore remedies. Caused by the herpes simplex virus, cold sores are spread from one person to another upon contact. They like to make an entrance in times of “concurrent illness — hence the name — or when you’re stressed, fatigued, or sleep deprived,” says dermatologist Hadley King, a clinical instructor of dermatology at the Weill Medical College of Cornell University, though sun exposure and injury to the area are potential triggers, too. A doctor can prescribe topical or oral Valtrex to minimize symptoms, but there are things to buy without a prescription, too. We asked two dermatologists for their recommendations on the best over-the-counter products to prevent and treat cold sores. Taking steps to prevent a cold sore is always better than waiting for the thing to rear its head and then doing damage control. Because cold sores are a viral infection, you may be able to prevent it the same way you would an incoming cold. Valaciclovir is a prodrug of acyclovir with more favourable bioavailability. Twice daily oral administration of valacyclovir is recommended in patients with genital herpes. A double-blind, randomized, controlled, multicriteria equivalence trial was conducted to determine whether od treatment with valacyclovir 1000 mg is as effective as bd treatment with 500 mg in patients with recurrent genital herpes. A total of 922 immunocompetent outpatients were treated with either regimen for 5 days; treatment was self-initiated at the first symptoms of the next recurrence. The principal outcome measures were the percentage of lesions healed at day 6, time to healing, time to cessation of pain, discomfort or itching, the percentage of abortive episodes and safety. Equivalence was assessed by comparison of 80% confidence limits for each measure; the two regimens were regarded as equivalent if the lower confidence limit was higher than a pre-determined equivalence limit calculated to show a maximum 10% inferiority of valacyclovir 1000 mg od against valaciclovir 500 mg bd. Intention-to-treat analysis showed that the two treatments were equivalent for each outcome measure.

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