Doxycycline was introduced into medical practice over 40 years ago but because of increasing bacterial resistance its value has decreased. It remains, however, the treatment of choice for infections caused by atypical organisms such as chlamydia, rickettsia, brucella and the spirochete. The attempt was made to characterize thoroughly doxycycline antibiotic and its effect on human health. Using keywords “doxycycline,” “vibramycin,” “parenteral injection,” “atypical bacteria” we performed a review of relevant mainly English articles based on a Medline search before May 2013, focusing on last five years. Doxycycline is primarily used in the treatment of infections of the upper and lower respiratory tract, as well as with gastrointestinal and sexually transmitted diseases. Furthermore, anti-inflammatory and immunomodulatory properties of doxycycline were found, which enable this medication to be used in the treatment of serious diseases, often with an immunological background or prophylactically, as a protective agent against the development of excessive inflammation in the human body. Moreover an anticancer effect of doxycycline has been described. Currently, doxycycline is rarely used, mainly because of the presence of a high percentage of drug-resistant strains of bacteria. If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history. In some cases, they may not be available in every strength or form as the brand-name version.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. This medicine may darken the color of your skin, nails, eyes, teeth, gums, or scars. Doxycycline may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. Doxycycline Capsules are used in the treatment of a variety of infections caused by susceptible strains of Gram-positive and Gram-negative bacteria and certain other micro-organisms. Escherichia coli, Streptococcus faecalis and other organisms. 1) Respiratory tract infections: Pneumonia and other lower tract respiratory tract infections due to susceptible strains of Streptococcus pneumoniae, Haemophilia influenzae, Klebsiella pneumoniae and other organisms. 3) Sexually transmitted diseases: Infections due to Chlamydia trachomatis including uncomplicated urethral, endocervical or rectal infections. 2) Urinary tract infections: Infections caused by susceptible strains of Klebsiella species, Enterobacter species. Non-gonococcal, urethritis caused by Ureaplasma urealyticum. Chancroid infections due to alymmatobacterium granulomatis. Alternative drug in the treatment of gonorrhoea and syphilis. 4) Dermatological infections: Acne vulgaris when antibiotic therapy is considered necessary. Since doxycycline is a member of the tetracycline series of antibiotics, it may be expected to be useful in the treatment of infections which respond to other tetracyclines, such as: 1) Ophthalmic infections: Due to susceptible strains of gonococci, staphylococci and Haemophilus influenzae. Doxycycline Capsules are indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence.
Applies to doxycycline: oral capsule, oral capsule extended release, oral powder for suspension, oral syrup, oral tablet, oral tablet delayed release Along with its needed effects, doxycycline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects of doxycycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to doxycycline: injectable powder for injection, oral capsule, oral delayed release capsule, oral delayed release tablet, oral kit, oral powder for reconstitution, oral syrup, oral tablet, oral and topical kit Very common (10% or more): Headache (up to 26%) Common (1% to 10%): Sinus headache Rare (0.01% to 0.1%): Bulging fontanels (in infants), benign intracranial hypertension (pseudotumor cerebri [symptoms include blurred vision, scotomata, diplopia]), tinnitus Frequency not reported: Hypoesthesia, increased intracranial pressure, paresthesia, somnolence, stupor, taste loss, drowsiness, amnesia, paresthesias of body areas exposed to sunlight, phrenic nerve paralysis after sclerotherapy Postmarketing reports: Pseudotumor cerebri, headache, dizziness Benign intracranial hypertension resulting in permanent loss of vision has been reported. A 70-year-old female patient with no significant medical history suddenly developed a severe headache followed by vomiting about 15 minutes after the initial dose of this drug. Doxycycline is used to treat infections caused by bacteria, including pneumonia and other respiratory tract infections; certain infections of the skin or eye; infections of the lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, infected animals, or contaminated food and water. It is also used along with other medications to treat acne. Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack), in people who may have been exposed to anthrax in the air, and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). Doxycycline can also be used in people who cannot be treated with penicillin to treat certain types of food poisoning. Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea (a skin disease that causes redness, flushing, and pimples on the face). Doxycycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne.
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