Azithromycin stability

By: Active Date: 21-Feb-2019
<strong>Stability</strong> and thermophysical properties of <strong>azithromycin</strong> dihydrate.

Stability and thermophysical properties of azithromycin dihydrate.

This medication is an antibiotic used to treat certain bacterial infections. This medication is known as a macrolide (erythromycin-type) antibiotic. This medication is used to treat lung infections (pneumonia) or female pelvic infections (e.g., PID) caused by bacteria. This medication is usually given by injection into a vein as directed by your doctor, usually once daily. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. Learn how to store and discard medical supplies safely. You should use this injectable medication only until you are able to take an antibiotic by mouth or until your treatment is finished. Dosage and length of treatment are based on your medical condition and response to therapy. For the best effect, use this antibiotic at evenly spaced times. The chemical stability of azithromycin (AZM) in aqueous solution has been investigated utilizing a stability-indicating LC assay with ultraviolet detection. The degradation kinetics were studied as functions of p H (4–7.2), buffer composition (phosphate, acetate, and citrate), buffer concentration, ionic strength, drug concentration and temperature. The observed rate obtained by measuring the remaining intact AZM was shown to follow pseudo-first-order kinetics. The maximum stability of AZM occured at an approximate p H 6.3 in 0.05 M potassium phosphate. The observed degradation rate increased with ionic strength, buffer concentration and obeyed the Arrhenius equation over the temperature range investigated (70–100 °C). The apparent energy of activation () had been predicted. Moreover, the degradation rate of AZM was independent on its initial concentration.

<b>Stability</b> and thermophysical properties of

Stability and thermophysical properties of

The degradation profile of azithromycin in buffered solutions was investigated using HPLC and found to be p H dependent in the range of 6.0–7.2. Desosaminylazitromycin, derived from hydrolytic loss of cladinose of the parent molecule, was the major degradation product at p H 6.0 but its amount progressively decreased moving toward p H 7.2. Two additional unreported degradation products were also observed and their structures were fully elucidated by MS- and NMR-spectroscopy to be associated with opening of the macrocyclic lactone ring. Azithromycin, produced by Pfizer under the brand name Zithromax or Azitrocin, has emerged as a very valuable antibiotic for the treatment of various infections in the cat. It is well tolerated, even by young kittens, and its efficacy in the treatment of upper respiratory infections (including bordetella and chlamydia), in particular, is unequalled by other anitbiotics. It is cleared very slowly from feline tissue, resulting in dosage schedules that are very convenient for the cat owner. A single dose maintains effective drug levels in the cat's tissues for as long as a week. The correct dose for the use of azithromycin in cats is 5 mg/kg (5 mg of drug for every 2.2 pounds of cat or 2.3 mg per pound of cat). Because of the persistance of this drug in feline tissues, DO NOT try to translate any protocol given for the use of this drug in humans and try to apply it to your cat. This mistake has been made by numerous veterinarians and pharmacists.

<b>Azithromycin</b>

Azithromycin

Azithromycin has relatively broad but shallow antibacterial activity. It inhibits some Gram-positive bacteria, some Gram-negative bacteria, and many atypical bacteria. A strain of gonorrhea reported to be highly resistant to azithromycin was found in the population in 2015. Neisseria gonorrhoeae is normally susceptible to azithromycin, Safety of the medication during breastfeeding is unclear. It has been reported that because only low levels are found in breastmilk and the medication has also been used in young children, it is unlikely that breastfed infants would suffer adverse effects. Most common adverse effects are diarrhea (5%), nausea (3%), abdominal pain (3%), and vomiting. Fewer than 1% of people stop taking the drug due to side effects. A azitromicina é um antibiótico da mesma família da claritromicina e da eritromicina. É considerada o primeiro antibiótico da classe dos “azalídeos”, cujos membros são derivados da classe dos macrolídeos, através da inserção de um átomo de nitrogênio no anel lactônico da eritromicina. Molecularmente, a azitromicina diferencia-se da eritromicina em dois aspectos: sua lactona é constituída por 15 membros e contém um átomo de nitrogênio, ao passo que a lactona da eritromicina é de 14 membros, não possuindo o átomo de nitrogênio. Essas diferenças são responsáveis pelas melhores características farmacológicas e microbiológicas da azitromicina: seu espectro de ação é mais amplo frente aos microorganismos Gram-positivos, sua difusão tecidual é mais rápida e mais elevada e sua meia-vida biológica é mais prolongada do que a de outros macrolídeos. É muito mais estável em meio ácido do que a eritromicina. Tem como mecanismo de ação a inibição da síntese proteica bacteriana através da sua ligação com a subunidade ribossomal SOB, impedindo assim a translocação dos peptídeos. Seu espectro de ação é semelhante ao da eritromicina.

<i>Azithromycin</i> Intravenous Uses, Side Effects, Interactions.
Azithromycin Intravenous Uses, Side Effects, Interactions.

Find patient medical information for Azithromycin Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. However, I have NOT done complete stability testing of azithromycin in solution personally. DO NOT take a "teaspoon of azithromycin and dissolve in X ml of water". The powder in the container does NOT have drug distributed evenly throughout it.

Azithromycin stability
Rating 4,7 stars - 646 reviews