The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. Below is a text only representation of the Patient Information Leaflet. The original can be viewed in PDF format using the link above. The text only version may be available from RNIB in large print, Braille or audio CD. For further information call RNIB Medicine Leaflet Line on 08. Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, which is converted to aciclovir in a persons body. Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism.
It slows the growth and spread of the herpes virus to help the body fight the infection. Valacyclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults. Valacyclovir is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least 2 years old. Valacyclovir will not cure herpes and will not prevent you from spreading the virus to other people. However, this medicine can lessen the symptoms of an infection. Before taking valacyclovir, tell your doctor if you have HIV/AIDS, a weak immune system, kidney disease (or if you are on dialysis), or if you have had a kidney or bone marrow transplant. Valacyclovir can be harmful to the kidneys, and these effects are increased when it is used together with other medicines that can harm the kidneys. Hetero Labs Limited is voluntarily recalling some prescription antiviral tablets manufactured for Camber Pharmaceuticals Inc. because the drugs were exposed to high temperatures during transport, according to the March 21, 2018, US Food and Drug Administration (FDA) Enforcement Report. The recall affects the following antivirals, which were shipped to New Jersey and then distributed across the United States: Hetero Labs initiated the recall February 13, 2018. The classification warns use of affected tablets could cause a temporary health problem. Both valacyclovir and valganciclovir tablets are prescription antiviral medications. Valacyclovir treats cold sores, chickenpox, shingles, and genital herpes, and valganciclovir is used to prevent and treat diseases caused by cytomegalovirus.
Mar 22, 2018. Both valacyclovir and valganciclovir tablets are prescription antiviral medications. Valacyclovir treats cold sores, chickenpox, shingles, and. Valacyclovir oral tablet is a prescription medication used to treat or prevent infections caused by the herpes simplex virus. These include cold sores.