When you have four or more migraines every month, your doctor may suggest you take a "preventive" medicine, instead of waiting to treat painful symptoms after they start. These drugs lower the chances that you'll have migraines in the first place. And when you do get one, it'll likely be briefer and less severe. Because of that, you may need to try more than one thing to find the treatment that's right for you. Your doctor will probably consider when and how often you get migraines and what other health problems you have. CGRP (calcitonin gene-related peptide) is a molecule involved in causing migraine pain. CGRP inhibitors are a new class of drugs that block the effects of CGRP. Erenumab (Aimovig) are fremanezumab (Ajovy) specifically approved to prevent migraine attacks. Also known as: Hemangeol, Inderal LA, Inderal XL, Inno Pran XLThe following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."I have been taking 80 mg of Propranolol per day for about 5 years for Migraine Prevention and High Blood Pressure. It's an added bonus for me that it also treats anxiety. I've always had mild anxiety and I blush very easily. I hardly get migraines now and I do feel calmer which is great since I had just begun to worry incessantly about my 3 kids, especially now that they are teenagers. In the beginning it made me tired but about 2 weeks later I got use to it. I believe I also have a bigger appetite and have gained about 10 pounds but to me it is worth it!
Sufficient evidence and consensus exist to recommend propranolol, timolol, amitriptyline, divalproex, sodium valproate, and topiramate as first-line agents for migraine prevention. There is fair evidence of effectiveness with gabapentin and naproxen sodium. Botulinum toxin also has demonstrated fair effectiveness, but further studies are needed to define its role in migraine prevention. Limited evidence is available to support the use of candesartan, lisinopril, atenolol, metoprolol, nadolol, fluoxetine, magnesium, vitamin B (riboflavin), coenzyme Q10, and hormone therapy in migraine prevention. Data and expert opinion are mixed regarding some agents, such as verapamil and feverfew; these can be considered in migraine prevention when other medications cannot be used. Evidence supports the use of timed-release dihydroergotamine mesylate, but patients should be monitored closely for adverse effects. 2 Preventive therapy, which can reduce the frequency of migraines by 50 percent or more, is used by less than one half of persons with migraine headache.3Following appropriate management of acute migraine, patients should be evaluated for initiation of preventive therapy. Choosing a therapeutic agent that is best for each individual patient requires consideration of the patient's history, lifestyle, comorbid conditions, and individual preferences. The beta-blocker propranolol also is FDA-approved as a preventive agent for migraines. Long-acting oral propranolol (Inderal), for example, is very useful in combination with the tricyclic antidepressant amitriptyline. Dosage begins with the long-acting agent given at 60 mg per day, and usually is kept between 60 and 120 mg per day. Lower doses, such as 20 mg twice per day of propranolol, sometimes are effective. Other b-blockers, such as metoprolol (Toprol XL) and atenolol, also are effective. Some of these are easier to work with than propranolol because they are scored tablets, and metoprolol and atenolol have fewer respiratory effects. Beta-blockers are useful for migraine patients with concurrent hypertension, tachycardia, mitral valve prolapse, and panic/anxiety disorders.
The studies show that sixty to seventy percent of all migraine subjects. use in the preventative treatment of migraine propranolol Inderal and Inderal LA and timolol. Usually, the patient will be started on a low dosage of the drug to test the. A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe. Typically, the headaches affect one half of the head, are.