Donepezil (Aricept®), ein selektiver reversibler Hemmstoff der Acetylcholinesterase, ist zugelassen zur symptomatischen Behandlung der leichten bis mittelschweren Alzheimer-Demenz. Die Tendenz der Verordnung ist stark steigend, ebenso wie bei den anderen Cholinesterasehemmern Galantamin (Reminyl®) und Rivastigmin (Exelon®). Wie in den Therapieempfehlungen der AkdÄ zur Demenz ausgeführt wurde, konnte nach sechsmonatiger Behandlungsdauer ein geringer, aber statistisch signifikanter positiver Effekt von Donepezil auf die kognitive Leistung, das globale Arzturteil und die Alltagskompetenz belegt werden; eine günstige Beeinflussung von Endpunkten wie Pflegebedürftigkeit und Progression der Alltagsbeeinträchtigung bleibt jedoch umstritten (1). Die häufigsten unerwünschten Arzneimittelwirkungen von Donepezil sind Übelkeit (16 %), Erbrechen (10 %), Diarrhö (13 %), Müdigkeit (8 %), Schlafstörungen (8 %) und Muskelkrämpfe (8 %) (2; 3). Es wird jetzt über einen 82-jährigen Patienten berichtet, der wegen Schwindel und Synkope stationär aufgenommen wurde (4). Er hatte zuvor für einen Monat Donepezil 10 mg/Tag zur Behandlung eines M. Andere Arzneimittel wurden nicht eingenommen, und eine kardiale Vorerkrankung bestand nicht. Bei der Krankenhausaufnahme lagen der Blutdruck bei 100/60 mm Hg und die Herzfrequenz bei 35/Minute. Das EKG zeigte einen kompletten AV-Block und nicht anhaltende ventrikuläre Tachykardien. Der Patient wurde mit einem temporären Schrittmacher versorgt und intensivmedizinisch überwacht. , one of the changes in the brain is a reduced number of nerve cells called cholinergic neurones. These are nerve cells that signal to other cells using a chemical called acetylcholine. Acetylcholinesterase inhibitors, such as donepezil, work by preventing acetylcholine from being broken down. This was to make the comparison as unbiased, or fair, as possible. We assessed the quality of all the studies we included. When it was sensible to do so, we analysed the results of studies together to get an overall result. Key results We included 30 studies with 8257 participants. Most of the people in the studies had mild or moderate , on scales measuring their cognitive function (e.g. thinking and remembering), how well they could manage their daily activities, and the overall impression of a trained researcher.
While there is currently no treatment for Alzheimer’s disease, a drug called Aricept can temporarily ease the symptoms for a short period of time. Aricept, also known as Donezepil, does not slow down the progression of the disease in the brain, but it can slow down further decline in cognition, usually for around six months. D., professor of psychiatry, neurology and gerontology at the Keck School of Medicine at University of Southern California. Aricept is an oral medication taken once daily that stops the breakdown of acetylcholine, a brain chemical that helps nerve cells communicate with one another. “They or a caregiver might see that they seem more attentive or interactive or engaged. Schneider said the benefits of Aricept are small, but should not be discounted entirely. It’s part of a class of drugs known as cholinesterase inhibitors. In studies, effectiveness has been gauged by patients scoring a few points better on tests of immediate memory and orientation—things like knowing what the date is, or having a slightly better sense of direction, said Schneider. But that doesn’t always translate to improvements outside of a clinical setting. “Sometimes these aren’t noticeable in day-to-day living,” said Schneider. “If a person is taking medication and is not sure that they’re benefiting, but not being hurt, either, we generally recommend people take the medication. Donepezil is approved in more than 90 countries around the world for the treatment of mild to moderate Alzheimer's disease, and is approved for the treatment of severe AD in the United States, Japan, Canada, and several other countries. The effect size of donepezil's benefits is small and the drug does not modify the underlying pathophysiology of the disease; even so, this symptomatic treatment has become a mainstay of Alzheimer's therapy in North America. Donepezil reversibly inhibits acetylcholinesterase (ACh E), the enzyme that degrades the neurotransmitter acetylcholine after its release from the presynapse. Donepezil and other acetyl cholinesterase inhibitors increase the availability of the acetylcholine in cholinergic synapses, enhancing cholinergic transmission. Donepezil was first approved to be marketed in the United States in 1996, with registration following suit in Canada and the European Union in 1997 and in many other countries shortly thereafter. In 2006/2007, regulatory approval was granted in the United States and Canada, but not in Europe, for its use in the treatment of severe Alzheimer's. Eisai's applications in the United States and Europe for regulatory approval of donepezil for vascular dementia in 20 were rejected and development for this indication stopped, though the drug is Besides the standard 5- and 10-mg tablets, a rapidly disintegrating tablet, as well as liquid, oral jelly, and transdermal formulations of donepezil have been developed, but thus far approved only in select countries.
No side effects for a few days and saw improvement in memory,then memory decreased over the next week. i called her doctor & said i was stopping the medication. Started at 5mg until problems started then cut pill in half, After 2 days of new dosage could tell memory functions were back up. She is back to knowing people and remembering was living alone at home, driving, etc, and because of gradually worsening memory, had been diagnosed with Alzheimers and prescribed Aricept. I didn't think the medication caused it because i thought that this was her illness, rapidly progressive. i prepared to institutionalize her, she was helpless. Within 2 or 3 days of stopping the medication, she was becoming her old self again, her functioning returned to previous level. in passing she said "sometimes the medications they give for dementia can cause the symptoms they are supposed to treat." I thought, "Bingo." if not for the complete fluke of this woman saying this in passing, i would have institutionalized my mom at 85. After that, for the next 4 years, she had part time in home help, she enjoyed her normal home life, going out with friends, watching TV, reading the paper, going to church, beauty shop, microwaving dinners at night, no weight loss, until 4 years later at age 89, she began going downhill fast and went into skilled nursing dementia unit for the next 9 years, dying at 98 of old age. toxic meds would have shortened her life and ruined the quality. This is a dreadful medication just speaking from my personal experience. The very first day I took it I was so sick with nausea, stomach pains, dizziness, feeling of ready to pass out and feeling like I was going to have a seizure all day long. I stopped taking it and it took me three days to get this out of my system. My stomach hurt so badly I thought I had been poisoned. Please read the side effects before considering taking this drug. This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. " March 7, 2012 -- The Alzheimer’s drug Aricept helps people with early to moderate signs of the disease maintain a higher level of function, but just how long the drug continues working is not fully understood. Aricept is the most widely prescribed medication in a class of Alzheimer’s drugs known as cholinesterase inhibitors. Close to 50% of people stop taking it within a year because of side effects such as weight loss, agitation, and fainting, or because they no longer see any improvements in their mental abilities. This raises the question of when to stop and what to do next. Now a new study may provide some much-needed clarity. Aricept can remain effective into the later stages of Alzheimer’s.
Considering stopping a medication such as Excelon, Namenda, Aricept or. In my clinical experience, I've witnessed a range of results after medications for. Results showed that continuing on Aricept gave a modest benefit over taking no drug, while switching to Namenda, also called memantine, provided a lesser one. While an analysis found no evidence.